The constant region affects antigen binding of antibodies to DNA by altering secondary structure
نویسندگان
چکیده
منابع مشابه
The constant region contributes to the antigenic specificity and renal pathogenicity of murine anti-DNA antibodies.
Affinity for DNA and cross-reactivity with renal antigens are associated with enhanced renal pathogenicity of lupus autoantibodies. In addition, certain IgG subclasses are enriched in nephritic kidneys, suggesting that isotype may determine the outcome of antibody binding to renal antigens. To investigate if the isotype of DNA antibodies affects renal pathogenicity by influencing antigen bindin...
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ژورنال
عنوان ژورنال: Molecular Immunology
سال: 2013
ISSN: 0161-5890
DOI: 10.1016/j.molimm.2013.04.004